Strengthen your defenses. Stay resilient and breathe easier - Yes, Strengthen my Defenses
GMP-Certified Manufacturing
Research-Driven Formulas
GPX - DEFENSE MODE
For Your Immunity, Your Airflow, and Your Resilience.
From Drained & Vulnerable to Resilient & Strong.
Support immune defenses
Optimize congestion & sinus pressure
Stay energized through cold & allergy seasons
Feel the Difference
Frequent Illness Drains You — But It Doesn’t Have to Anymore
Life Before
GPX - Defense Mode
Life Before GPX - Defense Mode
Occasional sinus pressure, stuffiness, or immune stressors
Always catching “what’s going around”
Feeling foggy, tired, and stuffy
Life After
GPX - Defense Mode
Life After GPX-Defense Mode
Fewer sick days, better airflow
More days of clear-headed energy
Stronger immunity & resilience
Feel the Difference
Built for Immunity Warriors
For those who:
Struggle with frequent colds or sinus issues
Deal with chronic allergies or sensitivities
Feel run-down or wiped out by minor illnesses
Want to support immune strength from the inside
Feel the Difference
The GPX - Defense Mode Formula
D-Core-GPX
Fuels immune cells with vitamin D and essential cofactors, helping strengthen your body’s frontline defenses against daily immune challenges.*
Vital C-GPX
A high-potency antioxidant blend supporting collagen production, immune resilience, and cellular protection to keep you energized and healthy year-round.*
IMUN-Axis
Breaks down stubborn mucus, relieves sinus pressure, and restores smooth, healthy airflow so you can breathe clearly and comfortably again.*
Biome-GPX
Boosts gut-powered immune defenses with powerful probiotics that strengthen your body from within for total system resilience and balance.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Feel the Difference
Why GPX - Defense Mode
Practitioner-Formulated
Designed by clinical experts who understand real-world gut challenges.
100% Potency Guarantee
What's on the label is what's in the capsule—no compromises.
Hypoallergenic
Free from common allergens—gentle on sensitive systems.
Empty Bottle Guarantee
Try it risk-free. Don't love it? Get your money back.
Non-GMO
No genetically modified ingredients. Ever.
GMP-Certified Manufacturing
Made in facilities that meet strict Good Manufacturing Practices.
Research-Driven Formulas
Every ingredient is backed by science and clinical studies.
3rd-Party Tested
Independent testing ensures safety, purity, and performance.
Feel the Difference
What’s Inside Your Daily Defense Pack
Morning Pack (A.M.)
1x D-Core-GPX
1x Vital C-GPX
1x IMUN-Axis
1x Biome-GPX
Evening Pack (P.M.)
1x Vital C-GPX
1x IMUN-Axis
1x Biome-GPX
Feel the Difference
GPX - Defense Mode
$104.60/ 3 months
$110.105% offQuantity
Support immune defenses
Optimize congestion & sinus pressure
Stay energized through cold & allergy seasons
Customer Reviews
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Clinically-Backed Ingredients for Real Results
GPX Defense Mode combines clinically-researched ingredients for full-spectrum immune support.
Every pack delivers key vitamins, antioxidants, probiotics, and botanical extracts designed to strengthen defenses, reduce inflammation, and promote resilient health.
Feel the Difference
Frequently Asked Questions
Ready to Feel Like Yourself Again?
Support your immune system, reduce sick days,
and reclaim your energy.
Feel the Difference
2025 © Copyright Dr. Steven Geanopulos. All rights reserved.
Research & Scientific Proofs
D-Core-GPX
1. Philippe Autier, MD; Sara Gandini, PhD. Vitamin D Supplementation and Total Mortality A Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2007;167(16):1730-1737.
2. Vogelsang H, Ferenci P, Resch H, et al. Prevention of bone mineral loss in patients with Crohn’s disease by long-term oral vitamin D supplementation. Eur J Gastroenterol Hepatol 1995;7:609-14.
3. Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med 2008;168:771-2.
4. Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics 2012;130:e561-e567.
5. Lansdowne ATG, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter.Psychopharmacology 1998;135:319-23.
6. Boucher BJ. Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’? Br J Nutr1998;79:315-27 [review].
7. Borissova AM, Tankova T, Kirilov G, et al. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003;57:258-61.
8. Nikooyeh B, Neyestani TR, Farvid M, et al. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr2011;93764-71.).
9. S. Bobo Tanner and Susan A. Harwell. More than healthy bones: a review of vitamin D in muscle health. Ther Adv Musculoskel Dis 2015, Vol. 7(4) 152–159.
Biome-GPX
1. D. Zabolotny, L. Shynkarenko, O. Melnikov, L. Volosevich, І. Zarytska, О. Goloborodko, G. Karpenko, О. Bolyska, D. Zabolotna. Application of the probiotic medication “Acidolor” (L.rhamnosus LB3) in patients with chronic tonsillitis and evaluation of its efficacy; Journal of ear, nose and throat diseases, No5, 2003, page.2-9.
2. D. Zabolotny, L. Volosevich, І. Zarytskа, V.D. Zabolotna. Perspectives of biotherapy in ENT diseases; Journal of ear, nose and throat diseases, No3-с, 2003, p.180-181.
3. O. Volska, D. Zabolotna. Study of the mechanisms of antagonistic activity of the Probiotics drugs. Journal of ear, nose and throat diseases, No3-с, 2003, p.164-165.
4. L. Shynkarenko, N. Dehtyrenko. Research of the Chemotherapy drugs influence on Lactic Acid Bacteria cells. Scientific news of the NTU “KPI”, 2004, 1 (33), pp.135-140.
5. Shynkarenko L., Dehtyrenko N. Adhesion potency of lactic acid bacteria as factor for selection of Probiotic strains. Scientific news of the NTU “KPI”, 2004, 3 (35), pp.102-106.
6. Zabolotny D., Melnilkov О., Zabolotnaya D., Shynkarenko L. Probiotic modulation of the immunogenesis in the experiment. Immunology and allergy, 1, 2006., p.19-21.
7. О. Melnikov, D. Zabolotnaya. Experimental investigation of the Probiotic influence on the palate tonsils cells in patients with chronic tonsillitis in vitro. The journal of ear, nose and throat diseases, 2006, 3, pp.24-27.
8. Volska, L. Shynkarenko, I. Zarytska, D. Zabolotna. Study of the possibility of the using of the Lactobacilli for treatment and prevention of the Candida infections in ENT-organs. Odessa medical Journal, 2006, 4 (96), pp.32-36.
9. О. Melnikov, D. Zabolotnaya, L. Kalinovskaya, V. Simonenko. Investigation of the functional and morphochemical characteristics of the cells and tissues under the conditions of the co-cultivation with L.rhamnosus B3. The journal of ear, nose and throat diseases, 4, 2007, 170-172.
10. Timoshok N, Shynkarenko L, Starovoytova S, Spivak N. Investigation of interferon induction activity of new Probiotic composition and strains L.delbrueckii 86, L.rhamnosus LB3 to compare with Del-Immune V and Lactobacterin (L.plantarum); 2009, IIX Congress of Ukrainian Microbiological Society, Abstracts Book, p.264.
11. Starovoytova S, Timoshok N, Gorchakov V, Spivak N. Immunomodulating abilities of Lactic Acid Bacteria.2009; Microbiol.J.,V71, 3, pp.41-47.
12. Report on clinical use of the probiotic cells Lactobacillus delbrueckii LE and their lysate. A.S Prylutskyy, MD, PhD, Clinical Immunology and Allergy Department, Donetsk State Medical University, 1999.
13. Savtova Z.D., Shpylevaya S.I., Tarutinov V.I., Rogatskaya V.P., NMeniok T.A., Nikolsky I.S., Mosienko V.S., Shynkarenko L.M., Chekhun V.F. Immune correction by an Immunomodulator from lactobacillus delbrueckii LE in a combined therapy of breast cancer at stages II and IV. Oncology 2000; 22:211-214.
14. Shpylevaya S.I., Tarutinov V.I., Mosienko V.S., Rogatskaya V.P., Ponomarev I.O., Shynkarenko L.M., Chekhun V.F. Correction of leucopenia by a new probiotic immunomodulator Lactobacillus delbrueckii product in combined treatment of breast cancer. Oncology, 2000; 2 (1-2):83-86.
15. D. Zabolotny, L. Shynkarenko, О. Melnikov, L. Volosevich, І. Zarytska, О. Goloborodko, G. Karpenko, О. Bolyska, D. Zabolotna. Application of the probiotic medication “Acidolor” in patients with chronic tonsillitis and evaluation of its efficacy; Journal of ear, nose and throat diseases, No5, 2003, page.2-9.
16. L. Shynkarenko, N. Dehtyrenko. Research of the Chemotherapy drugs influence on Lactic Acid Bacteria cells. Scientific news of the NTU “KPI”, 2004, 1 (33), pp.135-140.
17. Volska, L. Shynkarenko, I. Zarytska, D. Zabolotna. Study of the possibility of the using of the Lactobacilli for treatment and prevention of the Candida infections in ENT-organs. Odessa medical Journal, 2006, 4 (96), pp.32-3.
18. Starovoytova S., Gorchakov V. Lactic Acid Bacteria strain Selection for Effective Probiotics Compositions. 2006, Scientific News of NTU “KPI”, v5, pp.100-103.
19. Starovoytova S, Timoshok N, Gorchakov V, Spivak N. Interferon induction activity of Lactic Acid Bacteria; 2007, Immunology and Allergy (Ukrainian), #4, pp. 24-27.
20. Starovoytova S., Oryabinska L, Gorchakov V. Cholinesterase and protease activity of Lactic Acid Bacteria in vitro ; 2007, Environment and Health, #4 (43), pp.68-71.
21. Starovoytova S, Timoshok N, Spivak N. Influence of Lactic Acid bacteria associated cultures at mice experimental meningoencephalytic herpes infection; 2008, In Abstracts of International Conference “Antibacterial and anti-viral therapy on hospital treatment”, Charkov, Ukraine, pp.316-317.
22. Timoshok N, Shynkarenko L, Starovoytova S, Spivak N. Investigation of interferon induction activity of new Probiotic composition and strains L.delbrueckii 86, L.rhamnosus to compare with Del-Immune V and Lactobacterin (L.plantarum); 2009, IIX Congress of Ukrainian Microbiological Society, Abstracts Book, p.264.
23. Starovoytova S, Timoshok N, Gorchakov V, Spivak N. Immunomodulating abilities of Lactic Acid Bacteria.2009; Microbiol.J., V71, #3, pp.41-47.
IMUN-Axis
1. National Institute of Allergy and Infectious Diseases.
2. Anand, V., Ann Otol Rhinol Laryngol Suppl 113:2004.
3. Anand, V., Ann Otol Rhinol Laryngol Suppl 113:2004, inflation adjusted.
4. Prevent the Common Cold. (2017). Centers for Disease Control and Prevention. Retrieved 26 January 2017, from https://www.cdc.gov/features/rhinoviruses/.
5. American Academy of Otolaryngology – Head and Neck Surgery.
6. Juergens, U. R., Dethlefsen, U., Steinkamp, G., Gillissen, A., Repges, R., & Vetter, H. (2003). Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial.Respiratory medicine,97(3), 250-256.
7. Tesche, S., Metternich, F., Sonnemann, U., Engelke, J. C., & Dethlefsen, U. (2008). The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis.European Archives of Oto-Rhino-Laryngology,265(11), 1355.
8. Ryan R. A double blind clinical evaluation of bromelains in the treatment of acute sinusitis.Headache 1967;7:13-7.
9. Taub SJ. The use of bromelains in sinusitis: a double-blind evaluation.EENT Monthly 1967;46(3):361-5.
10. Seltzer AP. Adjunctive use of bromelains in sinusitis: a controlled study.EENT Monthly 1967;46(10):1281-8.
11. Thyme. Herbal Medicine: Expanded Commission E Monographs. American Botanical Council. 2000.
12. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70(4):293-8.
13. Cáceres DD, Hancke JL, Burgos RA, et al. Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. Phytomedicine 1999;6:217-223.
14. Hancke J, Burgos R, Caceres D, Wikman G. A double-blind study with a new monodrug Kan Jang: Decrease of symptoms and improvement in recovery from common colds.Phytother Res 1995;9:559-62.
15. Melchior J, Palm S, Wikman G. Controlled clinical study of standardized Andrographis paniculata extract in common cold-a pilot trial.Phytomedicine 1996;34:315-18.
16. Xia YF, Ye BQ, Li YD, Wang JG, He XJ, Lin X, Yao X, Ma D, Slungaard A, Hebbel RP, Key NS, Geng JG. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol 2004 Sep 15;173(6):4207-17.
17. Melchior J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardizedAndrographis paniculata Herba Ness extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection.Phytomedicine 2000;7:341-50.
18.Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97.
WARNING: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.
Vital C-GPX
1. Appel LJ, Moore TJ, Obarzanek E, et al: A clinical trial of the effects of dietary patterns on blood pressure: DASH CollaborativeResearch Group. NEJM 1997; 336: 1117-1124.
2. Taddei S, Virdis A, Ghiadoni L, et al:Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998; 97: 2222-2229.
3.Heller R, Unbehaun A, Schellenberg B, Mayer B,Werner-felmayer G,Werner ER. L-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin. J Biol Chem 2001; 276: 40-47.
4. Jaffe R. How to do an ascorbate (vitamin C) calibration (‘C Flush’) to determine personal need. HSC, January 2001.
5. Dawson EB, Evans DR, Harris WA,Teter MC, McGanity WJ.The effect of ascorbic acid supplementation on the blood lead levels of smokers. JACN. 1999: 18: 166-170.
6.Carr AC, Zhu BZ, Frei B.Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E).Circ Res 2000; 87(5): 349-54.
7.Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA.1993;90(17): 7915-22.
8.McCully K. Chemical pathology of homocysteine. III. Cellular function and aging. Ann Clin Lab Sci. 1994; 24(2): 134-52.
9.Anderson R, Smit MJ, Joone GK, Van Staden AM. Vitamin C and cellular immune functions. Protection against hypochlorous acid-mediated inactivation of glyceraldehyde-3-phosphate dehydrogenase and ATP generation in human leukocytes as a possible mechanism of ascorbate-mediated immunostimulation. Ann NY Acad Sci. 1990; 587: 34-48.